DNA as a Sensor of Hg Nanoparticles
Shikha Varma Institute of Physics, Bhubaneswar, India
Host: Cristina Marchetti
**NOTE: MONDAY SEMINAR**
Biomolecules can be used to provide control in organizing technologically important objects into functional nano-materials.
The interaction between biomolecules and inorganic materials is fundamental to these applications. These studies are expected to play role in the design of novel hybrid materials and new sensors for biological and non-biological objects. In our study we have utilized the DNA in two folds. Firstly we useDNA to fabricate self-assembled nanostructures of Hg. Secondly we demonstrate that the DNA can be used as a sensor of Hg nanoparticles. Mercuric nanoparticles (NP) have been fabricated within the DNA scaffold by site specific interactions. The NP get embedded within double helix and exclusively interact with the nucleic acid of DNA, having no influence on the phosphate backbone of DNA. Furthermore, conjugation of Hg NP with DNA exhibits a rectifying transport behavior, with the unreacted DNA displaying the ohmic behavior.
Formation of metal-base complexes as well as the modifications in transport (electrical) properties of DNA can be utilized as sensor of mercury contamination.
Penny Davis, administration questions