Spontaneous and induced cell polarization and collective migration - by Alex Mogilner
Alex Mogilner Courant Institute and Department of Biology, New York University
Host: Jen Schwarz | Contact: Matthias Merkel, firstname.lastname@example.org
Fish keratocyte cells served as the model system to understand biophysics of cell motility for decades. Recently, we combined experiment and modeling to understand the mechanism of polarization of these cells. We found that two essential feedbacks - positive one between myosin density and actin flow, and negative one between stick-slip adhesions and actin flow - underlie the motility initiation. Interestingly, keratocytes polarize in electric fields much faster but not stably, through different mechanism. I will also describe preliminary results on collective keratocyte migration in electric fields.